反応 #90286

反応方程式

hydrochloric acid

3,4-bis-benzyloxy-5-nitro-benzonitrile

sodium azide

ammonium chloride

→

5-(3,4-bis-benzyloxy-5-nitrophenyl)-2H-tetrazole

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度After cooling to room temperature
2. 2
   workup.ADDITIONthe reaction mixture was poured onto water (30 mL)
3. 3
   その他The resulting precipitate was collected
4. 4
   洗浄washed with water
5. 5
   その他dried

実験手順

A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitrophenyl)-2H-tetrazole, 0.53 g (87%).

出典