反応 #90240

反応方程式

oxalyl chloride

dimethylformamide

indole-3-carboxylic acid

oxalyl chloride

→

indole-3-carbonyl chloride

溶媒

DCM

反応条件

後処理

1. 1
   その他producing a clear, slightly yellow solution
2. 2
   その他This solution was evaporated to dryness in vacuo at 0.1 Torr
3. 3
   その他removal of excess oxalyl chloride
4. 4
   workup.DISSOLUTIONwas subsequently re-dissolved in 2 ml of dry DCM

実験手順

Next, a solution of indole-3-carbonyl chloride was prepared. A well-stirred suspension of indole-3-carboxylic acid (67.7 mg, 0.42 mmol) in dry DCM (2 ml) containing a small amount of dimethylformamide (DMF) (20 μL) was treated with oxalyl chloride (0.84 mmol, 107 mg, 72 μL) at 0° C. Following addition to the oxalyl chloride, the mixture was stirred for 20 minutes at 23° C., producing a clear, slightly yellow solution. This solution was evaporated to dryness in vacuo at 0.1 Torr to ensure removal of excess oxalyl chloride, and was subsequently re-dissolved in 2 ml of dry DCM.

出典