反応 #901

反応方程式

nitric acid

2-methyl-6-acetamidobenzoic acid

→

2-Methyl-3-nitro-6-acetamidobenzoic acid

溶媒

water

反応条件

後処理

1. 1
   その他are initially taken at -5° C.
2. 2
   workup.ADDITIONare added in portions
3. 3
   ろ過The deposited precipitate is filtered off with suction
4. 4
   洗浄washed with water
5. 5
   その他dried under reduced pressure at 50° C.

実験手順

271 ml of 98% nitric acid are initially taken at -5° C. and 106 g (0.55 mol) of the 2-methyl-6-acetamidobenzoic acid prepared in 1. are added in portions. After stirring at 10° C. for one hour, the reaction mixture is poured into a mixture of 540 g of ice and 270 ml of water. The deposited precipitate is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

出典