反応 #900

反応方程式

HCl

6-methylanthranilic acid

NaOH

acetic anhydride

→

2-Methyl-6-acetamidobenzoic acid

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONare then added dropwise
2. 2
   温度with cooling
3. 3
   ろ過the precipitate which deposits is filtered off with suction
4. 4
   洗浄washed with water
5. 5
   その他dried under reduced pressure at 50° C.

実験手順

90.6 g (0.6 mol) of 6-methylanthranilic acid are added to a solution of 24.8 g (0.62 mol) of NaOH in 500 ml of water and 63.4 g (0.62 mol) of acetic anhydride are then added dropwise. After stirring for one hour, the mixture is acidified to pH 3 with conc. HCl with cooling, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

出典