反応 #89922

反応方程式

HCl

HCl

4-methoxy-5-benzyloxy-2-(3-nitrobenzoylamino) benzamide

pyridine

→

6-(benzyloxy)-7-methoxy-2-(3-nitrophenyl)quinazolin-4(3H)-one

収率 47.0%

溶媒

NaOH

反応条件

後処理

1. 1
   その他A solid separated out
2. 2
   ろ過which was collected by filtration
3. 3
   洗浄washed with water (100 mL)
4. 4
   その他dried under vacuum

実験手順

A suspension of 4-methoxy-5-benzyloxy-2-(3-nitrobenzoylamino) benzamide (8.00 g, possesses some pyridine.HCl) in 4N NaOH (200 mL) was heated at 100±5° C. for 10 h. The reaction mixture was allowed to cool to room temperature and pH was adjusted to 7-7.5 with 6 N HCl. A solid separated out, which was collected by filtration, washed with water (100 mL) and dried under vacuum to give 6-(benzyloxy)-7-methoxy-2-(3-nitrophenyl)quinazolin-4(3H)-one (3.22 g, 7.99 mmol, 47% over two steps). MS 404 (M+1) HPLC retention time 8.026 min.

出典