反応 #89604

反応方程式

3,4-Dimethyl-pentanal

Dibutylamine

acetic acid

formaldehyde

→

3,4-dimethyl-2-methylene-pentanal

溶媒

toluene

反応条件

後処理

1. 1
   workup.WAITaged for another hour
2. 2
   温度The reaction mixture was cooled down
3. 3
   洗浄The reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L)

実験手順

Dibutylamine (34 g), acetic acid (15.78 g), and formaldehyde (230 g) were charged to a reaction flask and heated to 70° C. 3,4-Dimethyl-pentanal (500 g) was fed over 2 hours and aged for another hour. The reaction mixture was cooled down and toluene (200 mL) was added. The reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L) to provide the crude product 3,4-dimethyl-2-methylene-pentanal.

出典