反応 #89573

ord-8c426d448f92404ea77365e923e04078

反応方程式

CC(C)(C)OC(=O)N[C@@H](COC(F)F)C(=O)O
(S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionic acid
COC[C@H](N)C(=O)OCc1ccccc1.Cl
(S)-2-amino-3-methoxy-propionic acid benzyl ester, hydrochloride salt
→
COC[C@H](NC(=O)[C@H](COC(F)F)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1
(S)-2-((S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionylamino)-3-methoxy-propionic acid benzyl ester

反応物

CC(C)(C)OC(=O)N[C@@H](COC(F)F)C(=O)O
(S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionic acid
COC[C@H](N)C(=O)OCc1ccccc1.Cl
(S)-2-amino-3-methoxy-propionic acid benzyl ester, hydrochloride salt

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The compound of Formula II(b)(ii) was prepared as an off-white foam in a similar manner as the compound of Formula II(a)(ii)

実験手順

The compound of Formula II(b)(ii) was prepared as an off-white foam in a similar manner as the compound of Formula II(a)(ii), described above, from the compound of Formula IV(a), (S)-2-tert-butoxycarbonylamino-3-difluoromethoxy-propionic acid and the compound of Formula V(b), (S)-2-amino-3-methoxy-propionic acid benzyl ester, hydrochloride salt.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09441012B2uspto-grants-2016_09