反応 #89549

ord-7e7705626aba4ab081743a2f0fd2f531

反応方程式

Cc1c(F)ccc(C(=O)O)c1-n1nccn1
4-fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
C[C@@H]1CCCN[C@@H]1CN1C(=O)c2ccccc2C1=O
2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione
FC(F)(F)c1ccc(Cl)nc1
2-chloro-5-(trifluoromethyl)pyridine
→
Cc1c(F)ccc(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C(F)(F)F)cn2)c1-n1nccn1
title compound
Cc1c(F)ccc(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(C(F)(F)F)cn2)c1-n1nccn1
(4-Fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

反応物

Cc1c(F)ccc(C(=O)O)c1-n1nccn1
4-fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
C[C@@H]1CCCN[C@@H]1CN1C(=O)c2ccccc2C1=O
2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione
FC(F)(F)c1ccc(Cl)nc1
2-chloro-5-(trifluoromethyl)pyridine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared following the same general protocol as described in Example A318, using 4-fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione and 2-chloro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 477 (M+H).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09440982B2uspto-grants-2016_09