反応 #89280

反応方程式

5-bromo-2-methylpyridine 1-oxide

trimethylsilyl cyanide

triethylamine

→

title compound

3-Bromo-6-methylpicolinonitrile

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度The mixture was cooled to rt
2. 2
   濃縮concentrated in vacuo
3. 3
   その他The crude was purified by silica gel chromatography

実験手順

To the solution of 5-bromo-2-methylpyridine 1-oxide (8.935 g, 47.52 mmol) in acetonitrile (240 mL) was added trimethylsilyl cyanide (TMSCN) (25 mL, 190 mmol) and triethylamine (20 mL, 142.56 mmol). The reaction was heated at 100° C. for 16 h. The mixture was cooled to rt and concentrated in vacuo. The crude was purified by silica gel chromatography using 0-50% EtOAc in hexane to obtain the title compound.

出典