反応 #89279

反応方程式

5-bromo-2-methylpyridine

meta-chloroperbenzoic acid

NaHCO3

→

title compound

5-Bromo-2-methylpyridine 1-oxide

溶媒

CHCl3

反応条件

後処理

1. 1
   抽出The resulting mixture was extracted with DCM
2. 2
   洗浄washed with brine
3. 3
   乾燥dried (MgSO4)
4. 4
   その他The solvent was removed in vacuo
5. 5
   その他The crude was purified by silica gel chromatography (EtOAc/hexanes)

実験手順

A solution of 5-bromo-2-methylpyridine (10 g, 58.13 mmol) and meta-chloroperbenzoic acid (mCPBA, 30 g, 174.39 mmol) in CHCl3 (160 mL) was heated at 60° C. for 16 h. The mixture was cooled to rt and neutralized with satd. NaHCO3. The resulting mixture was extracted with DCM. The organic layers were combined and washed with brine and dried (MgSO4). The solvent was removed in vacuo. The crude was purified by silica gel chromatography (EtOAc/hexanes) to obtain the title compound.

出典