反応 #8905

反応方程式

product

Methyl 6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Cs2CO3

bromopinacolone

→

title compound

Methyl 6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(3,3-dimethyl-2-oxobutoxy)nicotinate

溶媒

DMF

反応条件

後処理

1. 1
   その他then partitioned between EtOAc and water
2. 2
   洗浄The organic layer was washed with water, brine
3. 3
   乾燥dried (MgSO4)
4. 4
   ろ過filtered
5. 5
   その他evaporated
6. 6
   その他The residue was purified on a silica gel flash chromatography column
7. 7
   洗浄eluted with 0–20% EtOAc-hexane
8. 8
   その他Evaporation of the purified fractions
9. 9
   その他drying in vacuo

実験手順

A 25 mL rb flask was charged with 1.111 g (2.97 mmol) of the product of Step B, 1.451 g (4.45 mmol) Cs2CO3, 10 mL DMF and finally 0.5 mL (3.71 mmol) of bromopinacolone. The reaction mixture was stirred at room temperature 1 h then partitioned between EtOAc and water. The organic layer was washed with water, brine, then dried (MgSO4), filtered and evaporated. The residue was purified on a silica gel flash chromatography column eluted with 0–20% EtOAc-hexane. Evaporation of the purified fractions and drying in vacuo afforded the title compound.

出典