反応 #88400

反応方程式

sodium hydroxide

methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

→

title compound

sodium 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

溶媒

methanol

反応条件

後処理

1. 1
   その他obtained in (Example 2.2) <Step 1>
2. 2
   温度the obtained mixture was then heated
3. 3
   温度to reflux for 15 minutes
4. 4
   workup.DISTILLATIONThereafter, the solvent was distilled away under reduced pressure

実験手順

An aqueous solution (1 ml) of sodium hydroxide (9.6 mg) was added to a methanol (1 ml) solution of the methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate (30 mg) obtained in (Example 2.2) <Step 1>, and the obtained mixture was then heated to reflux for 15 minutes. Thereafter, the solvent was distilled away under reduced pressure, and the residue was then subjected to azeotropy with toluene, so as to obtain a crude product of the title compound.

出典