反応 #88022

反応方程式

methyl 3-(N-methyl-N-(2-morpholinoethyl)sulfamoyl)-thiophene-2-carboxylate

THF

lithium hydroxide

→

3-(N-methyl-N-(2-morpholinoethyl)-sulfamoyl)thiophene-2-carboxylic acid

収率 83.7%

溶媒

H2O

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他The organic solvent was evaporated
3. 3
   ろ過the precipitate was collected by filtration

実験手順

To a solution of methyl 3-(N-methyl-N-(2-morpholinoethyl)sulfamoyl)-thiophene-2-carboxylate (Int. 47) (510 mg, 1.464 mmol) in a 1:1 mixture of THF and H2O, lithium hydroxide (351 mg, 14.64 mmol) was added, and the mixture was stirred at RT overnight. The organic solvent was evaporated and the aqueous residue was acidified with 2N HCl (pH=7); the precipitate was collected by filtration affording 3-(N-methyl-N-(2-morpholinoethyl)-sulfamoyl)thiophene-2-carboxylic acid (Int. 48) (410 mg, 1.226 mmol, MS/ESI+334.9 [MH]+).

出典