反応 #87964

反応方程式

dibromopropane

sodium chloride

HCl

LDA

ammonium chloride

thienoic acid

→

title compound

収率 123.5%

5-(3-bromopropyl)thiophene-2-carboxylic acid

収率 123.5%

溶媒

THF

反応条件

後処理

1. 1
   workup.STIRRINGwas stirred for 3 days
2. 2
   抽出The organic material was extracted with ethyl acetate
3. 3
   乾燥the organic layer was dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

To a solution consisting of thienoic acid (10 g, 78 mmol) in THF (150 mL) at −78° C. was added an LDA solution (85 mL, 170 mmol, 2 M in heptanes/THF/ethylbenzene, Sigma-Aldrich) dropwise over 20 minutes, and the reaction mixture was stirred 40 minutes. To the reaction mixture was then added dibromopropane (23.8 g, 117 mmol) in one portion, and the reaction mixture was allowed to warm to room temperature and was stirred for 3 days. To the reaction mixture was added 50 mL each of a saturated aqueous solution of ammonium chloride, a saturated aqueous solution of sodium chloride, and 6 N HCl. The organic material was extracted with ethyl acetate and the organic layer was dried over sodium sulfate, filtered, and concentrated to afford the title compound as a yellow oil (24.0 g). The product was used without further purification; TLC Rf 0.5 (solvent system: 30:70:1 v/v ethyl acetate-hexanes-acetic acid).

出典