反応 #8796

反応方程式

4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine

sodium hydride

5-piperidino-1-pentanol

→

4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine

溶媒

cyclohexane

反応条件

後処理

1. 1
   温度under reflux for 4 hours

実験手順

13.8 kg of 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine, 4.8 kg of 60% sodium hydride, 130 kg of cyclohexane and 10.6 kg of 5-piperidino-1-pentanol were stirred under reflux for 4 hours.

出典