反応 #8765

反応方程式

3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

potassium carbonate

2,4-difluorobenzylamine

→

title compound

(2,4-difluoro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他the compound is purified by column chromatography
2. 2
   workup.ADDITIONa graded solvent mixture of 5% ethyl acetate in dichloromethane to 10% methanol in ethyl acetate

実験手順

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 2,4-difluorobenzylamine and acetonitrile essentially as described above in example 18 except that the reaction is run overnight and the compound is purified by column chromatography using a graded solvent mixture of 5% ethyl acetate in dichloromethane to 10% methanol in ethyl acetate. Purity by LC/MS (APCI)=98%, [M+H]+=387.

出典