反応 #87647

反応方程式

2-chloro-4-methoxybenzoic acid

2,2,2-trifluoro-N-(hydroxymethyl)acetamide

H2SO4

→

desired product

収率 39.9%

5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid

収率 39.9%

反応条件

後処理

1. 1
   その他The title compound was prepared

実験手順

The title compound was prepared according to the procedure described in step-1 of Intermediate-26 by using 2-chloro-4-methoxybenzoic acid (0.060 g), 2,2,2-trifluoro-N-(hydroxymethyl)acetamide (0.050 g) and H2SO4 (2 mL) to afford 0.040 g of the desired product.

出典