反応 #87602

反応方程式

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture was refluxed for 18 h
2. 2
   濃縮The reaction mixture was concentrated
3. 3
   その他crude reaction mixture

実験手順

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

出典