反応 #87484

反応方程式

trityl chloride

benzyl chloride

D-glucose

trifluoromethane sulfonic acid

allyl alcohol

sodium hydride

D-glucose

→

((2R,3R,4S,5R)-6-allyloxy-3,4,5-tris-benzyloxy-tetrahydro-pyran-2-yl)-methanol

収率 54.0%

溶媒

triethylamine

triethylamine

反応条件

後処理

1. 1
   温度The mixture was cooled down to room temperature
2. 2
   その他the volatiles were removed in vacuo
3. 3
   workup.DISSOLUTIONthe residue dissolved in N,N-dimethylformamide (8 L)
4. 4
   その他This was split into four equal reactions
5. 5
   その他each reaction split in half
6. 6
   その他giving eight equal reactions
7. 7
   温度maintaining the reaction temperature between 40 to 50° C
8. 8
   workup.ADDITIONAfter complete addition
9. 9
   その他the reaction mixtures
10. 10
    workup.STIRRINGwere stirred at room temperature for 20 hours
11. 11
    workup.ADDITIONEach reaction was then poured onto ice/water (2 L)
12. 12
    抽出extracted with ethyl acetate (2.5 L)
13. 13
    洗浄The organic phases of each were washed with saturated brine/water (1:1, 2×2 L)
14. 14
    乾燥dried over magnesium sulfate (product Rf 0.85 in 3:1 hexanes/ethyl acetate)
15. 15
    ろ過After filtration and evaporation the residue
16. 16
    workup.DISSOLUTIONwas dissolved in a mixture of dichloromethane (16 L) and methanol (4 L)
17. 17
    その他The mixture was split into 5 equal portions
18. 18
    workup.ADDITIONto each was added sulfuric acid (32 mL)
19. 19
    workup.STIRRINGThe reactions were stirred for 3 hours
20. 20
    洗浄washed with brine/2M aqueous sodium hydroxide solution (1:1, 2×2 L)
21. 21
    乾燥dried over magnesium sulfate
22. 22
    ろ過After filtration and concentration in vacuo
23. 23
    その他the residue was further purified on silica gel eluting with 30% ethyl acetate in toluene
24. 24
    その他to give intermediate compound (I-1a)

実験手順

A suspension of D-glucose (1.2 kg, 6.6 mol), trifluoromethane sulfonic acid (12 mL) and allyl alcohol (5 L) was heated at 80° C. for 3 days. The mixture was cooled down to room temperature, the volatiles were removed in vacuo and the residue dissolved in N,N-dimethylformamide (8 L). This was split into four equal reactions and to each was added trityl chloride (463 g, 1.67 mol) and triethylamine (231 mL, 1.67 mol). A slight exotherm was observed while adding the triethylamine. The reaction mixture was stirred for 2 days at 30° C. and then each reaction split in half, giving eight equal reactions. To each of these reactions was added benzyl chloride (300 mL, 2.60 mol), followed by portionwise addition of sodium hydride (102.5 g, 2.60 mol) maintaining the reaction temperature between 40 to 50° C. After complete addition, the reaction mixtures were stirred at room temperature for 20 hours. Each reaction was then poured onto ice/water (2 L) and extracted with ethyl acetate (2.5 L). The organic phases of each were washed with saturated brine/water (1:1, 2×2 L), combined and dried over magnesium sulfate (product Rf 0.85 in 3:1 hexanes/ethyl acetate), After filtration and evaporation the residue was dissolved in a mixture of dichloromethane (16 L) and methanol (4 L). The mixture was split into 5 equal portions and to each was added sulfuric acid (32 mL). The reactions were stirred for 3 hours, washed with brine/2M aqueous sodium hydroxide solution (1:1, 2×2 L), combined and dried over magnesium sulfate. After filtration and concentration in vacuo, the residue was further purified on silica gel eluting with 30% ethyl acetate in toluene to give intermediate compound (I-1a) as a mixture of anomers (1.77 kg, 54% yield from D-glucose). Rf 0.15 in 3:1 hexanes/ethyl acetate.

出典