反応 #8741

反応方程式

3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

(3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

4-fluorobenzylamine

potassium carbonate

→

title compound

収率 94.0%

(4-fluoro-benzyl)-[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-amine

収率 94.0%

反応条件

後処理

1. 1
   濃縮Combine the appropriate fractions and concentrate

実験手順

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[(3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 4-fluorobenzylamine and potassium carbonate essentially as described above in example 4. Combine the appropriate fractions and concentrate to give the title compound (0.36 g, 94% Yield) as an oil. Purity by LC/MS (APCI)=100% area, [M+H]+=383 m/e.

出典