反応 #8732

反応方程式

sodium carbonate

3-fluorobenzylamine

1,2-dibromoethane

→

desired compound

(2-bromo-ethyl)-(3-fluoro-benzyl)-amine

溶媒

water

反応条件

後処理

1. 1
   その他Remove the unreacted 1,2-dibromoethane
2. 2
   workup.DISTILLATIONby distillation
3. 3
   抽出Extract the left-over residue with ether
4. 4
   その他evaporate

実験手順

Combine 3-fluorobenzylamine (5.0 g, 0.0400 mol), fused sodium acetate (3.28 g, 0.0400 mol) and 1,2-dibromoethane (7.51 g, 0.0400 mol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,2-dibromoethane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound. The compound can form the hydrochloride salt.

出典