反応 #872

反応方程式

N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine (R)-α-ethoxymethylbenzylamide

→

α-L-aspartyl-D-valine (R)-α-ethoxymethylbenzylamide

収率 50.3%

溶媒

methanol

water

water

反応条件

後処理

1. 1
   その他the catalyst was removed by filtration
2. 2
   濃縮the resulting filtrate was concentrated under reduced pressure to 5 ml
3. 3
   その他The crystal thus precipitated
4. 4
   その他was removed by filtration
5. 5
   その他dried

実験手順

To a suspension of 1.20 g (1.99 mmols) of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine (R)-α-ethoxymethylbenzylamide in 50 ml of methanol and 10 ml of water was added 0.30 g of 10% Pd-carbon (water content 50%). The mixture was reduced under hydrogen under heat at 40°C., 40 ml of water was added thereto, the catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure to 5 ml. The crystal thus precipitated was removed by filtration and dried to obtain 0.38 g (1.00 mmol, 50.3%) of α-L-aspartyl-D-valine (R)-α-ethoxymethylbenzylamide.

出典