反応 #87156

反応方程式

HCl

(S)-1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid

→

(S)-6-oxopiperidine-3-carboxylic acid

収率 144.5%

溶媒

dioxane

dioxane

反応条件

後処理

1. 1
   workup.STIRRINGThe reaction mixture was stirred for 4 h
2. 2
   濃縮concentrated to dryness
3. 3
   その他The residue was azeotroped three times with MeOH (10 mL for each portion)

実験手順

A solution of HCl in dioxane (6M, 10 mL) was added to a solution of (S)-1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid (700 mg, 2.90 mmol) in dioxane (5 mL) at 0° C. with stirring. The reaction mixture was stirred for 4 h and concentrated to dryness. The residue was azeotroped three times with MeOH (10 mL for each portion) to afford (S)-6-oxopiperidine-3-carboxylic acid (600 mg, quantitative) as a colorless solid. (R)-6-oxopiperidine-3-carboxylic acid was made in similar manner.

出典