反応 #87154

反応方程式

(R)-benzyl 2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoate

→

(R)-2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoic acid

収率 131.6%

溶媒

MeOH

反応条件

後処理

1. 1
   ろ過Pd/C was filtered off
2. 2
   洗浄washed with MeOH (5 mL)
3. 3
   濃縮concentrated to dryness

実験手順

Pd/C (10%, 1 g) was added to a solution of compound (R)-benzyl 2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoate (500 mg, 1.7 mmol) in MeOH (20 mL). The suspension was stirred under hydrogen atmosphere at ambient temperature for 2 h. Pd/C was filtered off and washed with MeOH (5 mL). The filtrate and washings were combined and concentrated to dryness to afford (R)-2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoic acid (450 mg, quantitative). (R)-2-((1S,3R)-3-hydroxycyclopentanecarboxamido)propanoic acid was obtained in a similar manner.

出典