反応 #871

反応方程式

HCl dioxane

N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine

→

(R)-α-ethoxymethylbenzylamine hydrochloride

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated under reduced pressure, 30 ml of ether
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   濃縮this was further concentrated

実験手順

12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.

出典