反応 #86945

反応方程式

ethyl acetate

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

4-methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride

triethylamine

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-4-methyl-2-(pyrazin-2-yl)thiazole-5-carboxamide

収率 56.5%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   その他This compound was obtained

実験手順

This compound was obtained following Method B starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.0486 g, 0.190 mmol), 4-methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride (0.047 g; 0.190 mmol), and triethylamine (0.067 mL; 0.475 mmol) in dichloromethane (3 mL). Flash chromatography on silica gel eluting with 3 to 30% of ethyl acetate in dichloromethane gave 0.0427 g (56%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-4-methyl-2-(pyrazin-2-yl)thiazole-5-carboxamide as a solid.

出典