反応 #869

反応方程式

HCl dioxane

N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine

→

(R)-α-methoxymethylbenzylamine hydrochloride

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITION30 ml of ether were added to the residue
3. 3
   濃縮this was further concentrated

実験手順

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

出典