反応 #86836

反応方程式

benzyl azide

ethyl propriolate

sodium ascorbate

→

ethyl 1-benzyl-1H-1,2,3-triazole-4-carboxylate

収率 24.0%

溶媒

water

tert-butanol

water

反応条件

後処理

1. 1
   その他the product crystallized out

実験手順

A solution of benzyl azide (0.200 mL; 1.61 mmol), ethyl propriolate (0.163 mL; 1.61 mmol), copper sulfate pentahydrate (0.016 mL, 1M solution in water), sodium ascorbate (0.161 mL; solution 1M in water) in a mixture of tert-butanol (3 mL) and water (3 mL) was stirred at room temperature overnight. The reaction mixture was diluted in water and the product crystallized out to furnish 0.090 g (24%) of ethyl 1-benzyl-1H-1,2,3-triazole-4-carboxylate as white crystals.

出典