反応 #86811

反応方程式

ethynylcyclopentane

ethyl 2-nitroacetate

ethanol

→

ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate

収率 96.0%

反応条件

後処理

1. 1
   その他The mixture was evaporated

実験手順

To a mixture of ethynylcyclopentane (0.74 mL; 6.05 mmol) and ethyl 2-nitroacetate (1.37 mL; 12.11 mmol) in ethanol (9 mL) in an Ace pressure tube was added 1,4-diazobicyclo[2.2.2]octane (DABCO, 0.070 g; 0.60 mmol). The tube was heated at 80° C. for 96 h. The mixture was evaporated. The flash chromatography on silica gel (eluent: 20 to 80% dichloromethane in heptane) of the residue provided 1.21 g (96%) of ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate as an oil.

出典