反応 #8677

反応方程式

diethyl 2-bromomalonate

potassium carbonate

8-oxa-3-azabicyclo[3.2.1]octane

8-Oxa-3-azabicyclo[3.2.1]octane

→

Diethyl 2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)malonate

溶媒

acetonitrile

反応条件

後処理

1. 1
   ろ過This is followed by filtration with suction and evaporation of the filtrate to dryness in a rotary evaporator
2. 2
   その他The residue is employed without further purification in the next stage

実験手順

4.72 g (19.8 mmol) of diethyl 2-bromomalonate are introduced into 30 ml of acetonitrile. Then 3.82 g (27.7 mmol) of potassium carbonate and 2.46 g (21.7 mmol) of 8-oxa-3-azabicyclo[3.2.1]octane from step 4 are added. The suspension is stirred at 50° C. overnight. This is followed by filtration with suction and evaporation of the filtrate to dryness in a rotary evaporator. The residue is employed without further purification in the next stage.

出典