反応 #86668

反応方程式

Carboxylic acid

(S)-2-Benzyloxycarbonylamino-but-3-enoic acid methyl ester

thionyl chloride

→

(S)-2-Amino-but-3-enoic acid methyl ester hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   温度This was cooled in ice
2. 2
   濃縮at rt for 18 h before being concentrated in vacuo
3. 3
   その他to afford a white solid, 0.388 g, (100%)

実験手順

Carboxylic acid 62 (0.350 g, 2.56 mmol) was suspended in methanol (10 mL). This was cooled in ice and 20% (v/v) thionyl chloride was added portionwise. The solution was stirred in ice for 1 h and then at rt for 18 h before being concentrated in vacuo to afford a white solid, 0.388 g, (100%).

出典