反応 #866

反応方程式

N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-isoleucine (S)-α-ethylbenzylamide

→

α-L-aspartyl-D-isoleucine (S)-α-ethylbenzylamide

収率 72.3%

溶媒

methanol

water

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration
2. 2
   濃縮the resulting filtrate was concentrated under reduced pressure
3. 3
   その他The crystals thus precipitated
4. 4
   ろ過were taken out by filtration
5. 5
   その他dried

実験手順

To a suspension of 2.81 g (4.7 mmols) of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-isoleucine (S)-α-ethylbenzylamide in 150 ml of methanol and 50 ml of water was added 2.0 g of 10% Pd-carbon (water content 50%). The mixture was reduced under hydrogen at room temperature for 5 hours. The catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure to be 20 ml. The crystals thus precipitated were taken out by filtration and dried to obtain 1.22 g (3.4 mmols) of α-L-aspartyl-D-isoleucine (S)-α-ethylbenzylamide.

出典