反応 #86472

反応方程式

TFA

tert-butyl (4-(4-isopropylpiperazin-1-yl)-2-nitrophenyl)carbamate

→

title compound

収率 115.0%

4-(4-isopropylpiperazin-1-yl)-2-nitroaniline

収率 115.0%

溶媒

DCM

反応条件

後処理

1. 1
   その他The resulting reaction mixture
2. 2
   その他Reaction progress
3. 3
   その他after completion of the reaction, excess solvents
4. 4
   その他were removed under reduced pressure
5. 5
   その他to afford a crude residue
6. 6
   洗浄The crude residue was repeatedly washed with ether

実験手順

TFA (3 mL) was slowly added to a stirred solution of tert-butyl (4-(4-isopropylpiperazin-1-yl)-2-nitrophenyl)carbamate (1.2 g, 3.29 mmol) in dry DCM (5 mL) under argon atmosphere at 0° C. The resulting reaction mixture was allowed to warm to room temperature and stirred for 12 hr. Reaction progress was monitored by LCMS, after completion of the reaction, excess solvents were removed under reduced pressure to afford a crude residue. The crude residue was repeatedly washed with ether to get the title compound (1 g, yield: 80.6%) as a red solid. MS (ESI): 265.1 [M+H]+.

出典