反応 #8625

反応方程式

water

Imidazole

homoserine

tert-Butyldimethylsilyl chloride

→

2-amino-4-(tert-butyldimethylsilanyloxy)butyric acid

溶媒

DMF

反応条件

後処理

1. 1
   workup.ADDITIONadded
2. 2
   workup.STIRRINGthe mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature
3. 3
   ろ過the resulting solid is collected by filtration
4. 4
   その他The isolated product is dried
5. 5
   その他used without further purification

実験手順

Imidazole (20.4 g, 300 mmol) is added to a solution of homoserine (11.9 g, 100 mmol) in DMF (100 mL) and the solution is stirred 15 minutes then cooled to 0° C. tert-Butyldimethylsilyl chloride (13.7 g, 91 mmol) added and the mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature. The reaction mixture is poured into water (3 L) and the resulting solid is collected by filtration. The isolated product is dried and used without further purification.

出典