反応 #86153

反応方程式

tert-butyl 4-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate

→

tert-butyl 4-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]piperidine-1-carboxylate

溶媒

ethanol

反応条件

後処理

1. 1
   その他18 h
2. 2
   ろ過The reaction was filtered through celite
3. 3
   洗浄wash with MeOH

実験手順

A mixture of tert-butyl 4-[6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (125 mg, 0.266 mmol) and palladium on activated carbon, reduced 10% (28 mg, 0.0266 mmol) in ethanol 10.0 mL was stirred under H2 balloon at 40° C. 18 h. The reaction was filtered through celite and wash with MeOH. The crude product was carried to next step.

出典