反応 #86130

反応方程式

tert-butyl 4-(6-(6-(1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepane-1-carboxylate

oxirane

→

solid

収率 71.0%

2-(4-(1-(6-(1,4-Diazepan-1-yl)pyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1H-pyrazol-1-yl)ethanol

収率 71.0%

反応条件

実験手順

Following the procedures as described in Example 61 and starting with tert-butyl 4-(6-(6-(1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepane-1-carboxylate and oxirane, 152 was obtained as a light yellow solid (102 mg, 71%) over two steps. 1H NMR (500 MHz, CDCl3) δ (ppm) 8.941-8.942 (d, J=0.5 Hz, 1H), 8.57 (s, 1H), 8.17 (s, 1H), 8.07 (s, 1H), 7.86 (s, 1H), 7.57-7.60 (t, J=16 Hz, 1H), 7.22-7.26 (t, J=20.5 Hz, 1H), 6.36-6.37 (d, J=8 Hz, 1H), 4.30-4.32 (t, J=9.5 Hz, 2H), 4.05-4.07 (t, J=9.5 Hz, 2H), 3.77-3.82 (m, 4H), 3.11-3.13 (t, J=10.5 Hz, 2H), 2.88-2.91 (t, J=11.5 Hz, 2H), 2.26 (s, 2H), 1.97-2.01 (m, 2H); MS (ESI) m/z: 405 [M+H]+.

出典