反応 #86040

反応方程式

2-amino-3-bromopyridine

ethoxycarbonyl isothiocyanate

→

ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate

収率 100.1%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他dichloromethane was removed in vacuo

実験手順

To a solution of 2-amino-3-bromopyridine (50.0 g, 289 mmol, 1 equiv) in dichloromethane (500 mL) was added dropwise ethoxycarbonyl isothiocyanate (39.0 g, 297 mmol, 1.03 equiv) at room temperature. After 2 h, dichloromethane was removed in vacuo to provide crude ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate (88 g).

出典