反応 #86028

反応方程式

(R)-2-t-Butyloxycarbonylamino-2-ethoxycarbonylsuccinimide

hydrochloric acid

→

title compound

収率 97.0%

(R)-2-amino-2-ethoxycarbonylsuccinimide hydrochloride

収率 97.0%

溶媒

—

solution

ethyl acetate

反応条件

後処理

1. 1
   濃縮concentrated under reduced pressure
2. 2
   ろ過filtered

実験手順

(R)-2-t-Butyloxycarbonylamino-2-ethoxycarbonylsuccinimide (380 mg) obtained in Example 16 was dissolved in a 4 mol/L solution of hydrochloric acid in ethyl acetate (8 mL), and the reaction mixture was stirred for 1 hour, and then concentrated under reduced pressure. The residue was suspended in ether and filtered to obtain the title compound (288 mg, yield: 97%) as white crystals. Optical rotation [α]D25 was −14.8° (c 1.0, methanol). Optical purity was 75.6% ee.

出典