反応 #85914

反応方程式

4-bromo-N-methylaniline

K2CO3

2-bromoethanol

→

brown oil

収率 19.0%

2-((4-bromophenyl)(methyl)amino)ethanol

収率 19.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他The mixture was reacted at 100° C. for 2 days
2. 2
   抽出Then it was extracted by EA and brine
3. 3
   洗浄washed by brine
4. 4
   乾燥dried over Na2SO4
5. 5
   濃縮concentrated
6. 6
   その他purified by flash chromatography, (PE: EA=10:1 to 3:1)

実験手順

4-bromo-N-methylaniline (700 mg, 3.76 mmol) was dissolved in DMF (20 mL), K2CO3 (1.56 g, 11.29 mmol) and 2-bromoethanol (1.41 g, 11.29 mmol) were added in. The mixture was reacted at 100° C. for 2 days. Then it was extracted by EA and brine, washed by brine, dried over Na2SO4, concentrated and purified by flash chromatography, (PE: EA=10:1 to 3:1) to give 164 mg brown oil.

出典