反応 #85859

反応方程式

N-Boc-3-piperidone

THF

KCN

NaHSO3

→

title compound

収率 100.4%

tert-butyl 3-cyano-3-hydroxypiperidine-1-carboxylate

収率 100.4%

溶媒

H2O

H2O

DCM

反応条件

後処理

1. 1
   乾燥the combined extracts were dried by Na2SO4
2. 2
   ろ過filtered
3. 3
   その他evaporated

実験手順

To a solution of N-Boc-3-piperidone (5.00 g, 25.1 mmol) and THF (15 mL) was added KCN (2.34 g, 37.6 mmol) and H2O (15 mL) and the resulting solution was cooled to 0° C. To the resulting homogeneous orange solution was added a solution of NaHSO3 (1.25 g, 37.6 mmol) and H2O (15 mL). The resulting solution was stirred at 0° C. for 1 hour. The solution was twice extracted DCM and the combined extracts were dried by Na2SO4, filtered and evaporated to afford title compound 5.7 g as white solid. MS (m/z): 127 (M+H-Boc)+

出典