反応 #85807

反応方程式

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

1-bromo-2-(2-bromoethoxy)ethane

DIPEA

→

title compound

4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine

溶媒

THF

反応条件

後処理

1. 1
   温度at reflux overnight
2. 2
   濃縮The mixture was concentrated
3. 3
   workup.ADDITIONdiluted with water
4. 4
   抽出extracted with EtOAc
5. 5
   乾燥The combined extracts were dried over Na2SO4
6. 6
   ろ過filtered
7. 7
   濃縮concentrated
8. 8
   その他The residue was purified by preparative thin-layer chromatography

実験手順

A solution of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine (164 mg, 0.75 mmol), 1-bromo-2-(2-bromoethoxy)ethane (418 mg, 1.8 mmol), and DIPEA (0.64 mL, 3.6 mmol) in THF (2 mL) was stirred at reflux overnight. The mixture was concentrated, diluted with water, and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative thin-layer chromatography to give the title compound. MS (m/z): 290 (M+H)+.

出典