反応 #85793

反応方程式

2,6-dichloropyridine-4-ylamine

nitric acid

→

title compound

N-(2,6-dichloropyridin-4-yl)nitramide

溶媒

sulfuric acid

反応条件

後処理

1. 1
   その他the internal reaction temperature <10° C
2. 2
   その他the reaction temperature below 0° C.
3. 3
   その他of 40 minutes

実験手順

2,6-dichloropyridine-4-ylamine (10.0 g, 61 mmol) was slowly added in concentrated sulfuric acid (64 mL) at the rate to keep the internal reaction temperature <10° C. The mixture was then cooled to −5° C. and nitric acid (90%, 30 mL) was added dropwise to keep the reaction temperature below 0° C. over a period of 40 minutes. The reaction mixture was stirred at 0° C. for 2 hours and then poured into ice-water (500 mL). The title compound was isolated by filtration and dried in vacuo for the next step.

出典