反応 #85694

反応方程式

5-(4-chlorophenyl)isoxazole-3-carbaldehyde

(R)-2-methylpropane-2-sulfinamide

→

(R,E)-N-((5-(4-chlorophenyl)isoxazol-3-yl)methylene)-2-methylpropane-2-sulfinamide

溶媒

1,2-dichloroethane

反応条件

後処理

1. 1
   温度The reaction was then cooled to room temperature
2. 2
   ろ過filtered through a pad of celite
3. 3
   洗浄to wash through
4. 4
   濃縮The filtrate was concentrated in vacuo

実験手順

A suspension of 5-(4-chlorophenyl)isoxazole-3-carbaldehyde (2.00 g, 9.63 mmol), (R)-2-methylpropane-2-sulfinamide (1.28 g, 10.6 mmol, 1.1 equiv) and anhydrous copper(II) sulfate (2.31 g, 14.5 mmol, 1.5 equiv) in 1,2-dichloroethane (19 mL) was heated at 55° C. for 2-18 hours. The reaction was then cooled to room temperature and filtered through a pad of celite, using 1,2-dichloroethane to wash through. The filtrate was concentrated in vacuo to give crude (R,E)-N-((5-(4-chlorophenyl)isoxazol-3-yl)methylene)-2-methylpropane-2-sulfinamide as a green solid, which was used without further purification. MS m/z 311.0 (M+H)+; Rt-1.11 min.

出典