反応 #85558

反応方程式

benzothiazol-2-yl-(dihydrofuran-2-ylidene)-acetonitrile

hydrazine hydrate

→

title compound

収率 67.0%

3-(5-Amino-4-benzothiazol-2-yl-2H-pyrazol-3-yl)-propan-1-ol

収率 67.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the resulting residue was triturated with dichloromethane
3. 3
   その他The solid was isolated by filtration
4. 4
   洗浄was then washed with dichloromethane and methanol

実験手順

The benzothiazol-2-yl-(dihydrofuran-2-ylidene)-acetonitrile (90 mg, 0.37 mmol) prepared above and hydrazine hydrate (25 mg, 0.5 mmol) were refluxed in ethanol (15 mL) for 10 hours. The solvent was evaporated and the resulting residue was triturated with dichloromethane. The solid was isolated by filtration and was then washed with dichloromethane and methanol to yield 60 mg (67%) of the title compound as a cream coloured solid. MS (m/z, ES+): 275.1 (M+1, 100). 1H NMR (300 MHz, ppm, DMSO-d6): δ (ppm), 11.5-12.2 (br s, 1H), 8.00 (d, 1H), 7.86 (d, 1H), 7.77 (t, 2H), 7.29 (t, 1H), 7.00-5.20 (br m, 2H), 4.55 (s, 1H), 3.52 (q, 2H), 2.83 (br s, 2H), 1.84 (q, 2H).

出典