反応 #85528

ord-52573d8293704418bd3309663f2bdf96

反応方程式

Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)Cl)cc2s1
2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride
NCc1ccc(F)cc1
4-fluorobenzylamine
CN1CCOCC1
NMM
Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCc3ccc(F)cc3)cc2s1
title compound
収率 9.0%
Cc1n[nH]c(N)c1-c1nc2ccc(S(=O)(=O)NCc3ccc(F)cc3)cc2s1
2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonic acid 4-fluoro-benzylamide
収率 9.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

the title compound (8 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (75 mg, 0.23 mmol), 4-fluorobenzylamine (29 μL, 0.25 mmol) and PS-NMM (0.22 g, 0.45 mmol) in 4 mL of chloroform. MS (m/z, ES+): 418.3 (M+1, 100%). Yield=9%.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09434720B2uspto-grants-2016_09