反応 #85515

反応方程式

Ammonium hydroxide

2-aminobenzenethiol

3-aminopyrazole-4-carbonitrile

→

title compound

収率 40.5%

4-Benzothiazol-2-yl-1H-pyrazol-3-ylamine

収率 40.5%

溶媒

反応条件

後処理

1. 1
   その他The resulting yellow solid was isolated by filtration
2. 2
   洗浄washed with cold water

実験手順

A mixture of 2-aminobenzenethiol (100 mg, 0.8 mmol) and 3-aminopyrazole-4-carbonitrile (86 mg, 0.8 mmol) in 3 g of polyphosphoric acid was heated at 200° C. for 3 hours. The mixture was then poured into ice water and was neutralized with conc. Ammonium hydroxide solution. The resulting yellow solid was isolated by filtration and washed with cold water to yield the title compound (70 mg, 40%). MS (m/z, ES+): 217 (M+1, 100%); 1H NMR (300 MHz, ppm, DMSO-d6): δ 7.97 (d, 3J=7.8 Hz, 1H), 7.88 (s, 1H), 7.84 (d, 3J=8.0 Hz, 1H), 7.42 (m, 1H), 7.29 (m, 1H), 6.3 (br s, 2H).

出典