反応 #85508

反応方程式

4-nitrobenzenesulfonyl chloride

triethylamine

methylamine

→

4-nitrobenzenesulfonic acid methylamide

溶媒

Brine

THF

THF

反応条件

後処理

1. 1
   抽出the reaction solution was extracted with ethyl acetate
2. 2
   乾燥The combined organic extracts were dried over sodium sulfate
3. 3
   ろ過filtered
4. 4
   その他evaporated

実験手順

To an ice cold solution of 4-nitrobenzenesulfonyl chloride (2.7 g, 12 mmol) and triethylamine (27 mmol) in 60 mL of dry THF was added methylamine (8 mL of a 2 M solution in THF, 16 mmol). The mixture was stirred at room temperature overnight. Brine was added and the reaction solution was extracted with ethyl acetate. The combined organic extracts were dried over sodium sulfate, filtered, and evaporated to yield 4-nitrobenzenesulfonic acid methylamide as an oil. The crude material was used in the subsequent reaction without further purification.

出典