反応 #84924

ord-4304d1d4dacb420f9389b0f928691396

反応方程式

CC(C(=O)OC(C)(C)C)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate
O=C(O)C(F)(F)F
TFA
→
CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
2-[4-(2-Bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

反応物

CC(C(=O)OC(C)(C)C)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate
O=C(O)C(F)(F)F
TFA

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

920 mg (2.2 mmol) of tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 1110 mg (purity 93%, quant.)

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09434690B2uspto-grants-2016_09