反応 #8490

反応方程式

5-fluoro-2-methylbenzonitrile

N-bromosuccinimide

→

product

収率 102.0%

2-Bromomethyl-5-fluorobenzonitrile

収率 102.0%

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   温度was refluxed for 18 h
2. 2
   ろ過filtered through fritted glass
3. 3
   洗浄The solid in the funnel was washed with carbon tetrachloride (3×50 mL)
4. 4
   その他evaporated to dryness under vacuum

実験手順

A mixture of 5-fluoro-2-methylbenzonitrile (10.0 g, 74.0 mmol), N-bromosuccinimide (NBS, 13.2 g, 74.0 mmol), benzoyl peroxide (0.2 g, 0.82 mmol), and carbon tetrachloride (100 mL) was refluxed for 18 h. The reaction mixture was then cooled to room temperature and filtered through fritted glass. The solid in the funnel was washed with carbon tetrachloride (3×50 mL) and evaporated to dryness under vacuum to provide 16.1 g, 102% yield of product.

出典