反応 #8481

反応方程式

epichlorohydrin

product

2-[4-hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

potassium hydroxide

→

title compound

2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

溶媒

dichloromethane

methanol

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   洗浄the filtrate washed with water
3. 3
   その他dried
4. 4
   ろ過sodium sulfate filtered
5. 5
   その他evaporated

実験手順

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

出典